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The Significance of Oral Fluid Antigen Rapid Test in the Time of the COVID-19 Epidemic

Zhang Lei, Yang Feng and Zhu Junzhe

Objective: Explore the performance of different test methods in detecting COVID-19 PCR, antibodies and antigens.

Methods: Compare the sensitivity, specificity and the accuracy of different manufacturers’ COVID-19 antibody and antigen rapid tests. Different onset time samples were tested with RT-PCR and COVID-19 antibody and antigen rapid tests. The sample used for rapid detection of COVID-19 antigen was oral fluid. Three kinds of sample used in the detection of novel coronavirus antibodies were venipuncture/ fingerstick whole blood, serum and plasma.

Results: The detection rate of covid-19 antibody was increased with the increase of the onset time of patients, while the detection rate of antigen was decreased gradually, which was corresponding to the nature of antigen and antibody in the human body.

Conclusion: Different detection methods have their own advantages in different application fields. In antigen and antibody detection, we through products (Abbott, Roche, Healgen, AllTest, Citest, Siemens, Lepu, Wondfo) to predict the advantages of convenient and sample collection, high throughput, low workload, high reproducibility and low cost in practical applications.