To compare the performance differences between transdermal products, in vitro drug release tests are often utilised and mandated by numerous authorities. The outcome, however, is insufficient to make a reliable prediction of the drug release in vivo. The traditional USP apparatus 2 and 5 methods and a new approach for assessing drug release from patches have both been investigated in this study. On a synthetic skin simulator, durogesic patches—used here as a model patch—were applied, and three moisture levels (29, 57, and 198 L cm2) were assessed. The artificial skin simulators were taken out at 1, 2, 3, 4, 6, and 24 hours and removed using a hydrochloric acid solution with a pH of 1.0. Isocratic reverse phase high-pressure liquid chromatography was used to determine the drug concentrations in the extractions. The outcomes demonstrated that the drug release rate increased as the moisture level on the synthetic skin simulator rose. The new approach's medication release outcomes had a better association with the release rate stated on the product label than the traditional USP method did. In the early stages of development, this innovative technique may be able to distinguish between the drug releases rates of various transdermal drug delivery system formulations.
Poor skin permeability makes it difficult to deliver drugs via transdermal (TRD) delivery at the necessary therapeutic rate. Using the complementary effects of skin electroporation and gold nanoparticle (GNP), a unique TRD enhancement technique was developed in the current work. The model medicine chosen was diclofenac sodium (DS). The polyvinyl alcohol/poly (dimethyl siloxane)-g-polyacrylate skin adhesive matrix was used to create an electro-sensitive patch. To improve skin permeability and electrical conductivity, respectively, GNP/carbon nanotube nanocomposite (GNP-CNT) was introduced into the matrix using GNP and CNT. By adjusting the GNP-CNT concentration, it is possible to fine-tune the device's characteristics by changing the device's thermomechanical properties, water vapour permeability (WVP), drug encapsulation efficiency (DEE), and drug release profile.
Published Date: 2022-07-28; Received Date: 2022-06-29
