Manar Zraikat, Steve Shnyder, Helen Sheldrake and Laurance Patterson
Tumour dissemination is a major reason for failure of therapy for many tumour types. Metastasis and angiogenesis result from the interaction between the tumour cells in the tumour microenvironment. The detailed picture of tumour and the tumour microenvironment interaction however is not fully understood due to a lack of representative models. This review shows a brief summary of the assays and models used to describe the tumour dissemination process.