Archives of Medicine

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Two Forms of Presentation of Confirmed Sporadic Creutzfeldt-Jakob Disease

A Lopez Serrano, S Banon Escandell, Castano Pérez, P Safont Gaso, P Esteve Atienzar, J Peris García, JM Seguí Ripoll

Prion diseases are a rare type of neurodegenerative disease, and the sporadic Creutzfeldt-Jakob subtype is the most common. The disease occurs worldwide with an incidence of 1 case per million population per year. Prion protein (PrP) gene polymorphism without genetic mutation results in an aberrant protein isoform being deposited intraneuronally, leading to spongiform neuronal degeneration. We report on two patients who were admitted to our Service with systemic and neurological disease, with fatal end after 14 and 9 months of follow-up, respectively. Diagnosis was confirmed by histologic examination of the brain.