SYNTHESIS OF NEWER HETEROCYCLIC MOLECULES USING COMBINATION OF BENZIMIDAZOLE AND PYRAZOLE

Benzimidazole and pyrazole are heterocyclic compound that play crucial roles in the function of a number of biologically important molecules. Benzimidazole and pyrazole derivatives have shown different therapeutic properties such as antiulcer, antihelminthic, antihypertensive, anticoagulant, antiallergic, analgesic, anti-inflammatory, antimicrobial, antiviral, antiparasitic, antioxidant etc. As per the literature the by simple nucleophillic reaction we formed the 1-(1Hbenzoimidazol-1-yl)-2-chloroethanone. Then addition reaction with hydrazine to give 2-(1H-benzo[d]imidazol-1-yl) acetohydrazide. After that we use ethylacetoacatate to give 1-(2-(1H-benzo[d]imidazol-1-yl) acetyl)-3-methyl-1H-pyrazol-5(4H)-one by cyclisation. Followed by addition of different aldehyde to give newer heterocyclic derivatives. These all newer compounds were characterized by IR, MASS and NMR spectroscopy.