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Editorial - (2016) Volume 7, Issue 4

Gastrointestinal Dysfunction in Parkinson’s Disease and Its Initiation at Gut

Talukdar Debjyoti1, Patil Annasaheb2 and Patil Ashish1

1Department of Medical Research, All Saints University School of Medicine, Roseau, Dominica

2Department of Orthopedics, Gadag Institute of Medical Sciences, Gadag, Karnataka, India

*Corresponding Author:

Patil Ashish
Department of Medical Research
All Saints University School of Medicine
Roseau, Dominica
Tel: +1 866-602-9555
E-mail: [email protected]

Received Date: September 30, 2016; Accepted Date: October 03, 2016; Published Date: October 10, 2016

Citation: Debjyoti T, Annasaheb P, Ashish P. Gastrointestinal Dysfunction in Parkinson’s Disease & its Initiation at Gut. Transl Biomed. 2016, 7:4. doi:10.2167/2172-0479.100091

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Editorial

Parkinson’s disease is a growing neurological disorder. The gastrointestinal dysfunction [1] of Parkinson’s disease manifest most prominently in form of Constipation. It is estimated that more than half-a-million people are suffering from this dreadful neurodegenerative disorder in US alone. A recent study conducted by University of Iowa shows that Parkinson’s disease is related to gut [2]. It is seen that various complications including constipation along with digestive dysfunction occurs at various stages of Parkinson’s disease. Moreover, researchers were also able to link a poison named rotenone which when exposed to roundworms leads to killing of neurons whose death is related to Parkinson’s [3]. Apart from that, it has also been found that Parkinson’s disease initiates in the gut along with the onset of central motor symptoms [4]. Moreover, it has been found that occurrence of gut inflammation leads to central nigrostriatal neurodegeneration which causes bowel neuromotor abnormalities along with oxidative stress and tissue inflammations. Overall, it has been observed that the gut microbiota may be involved in the process of spreading the neurodegenerative cascade of Parkinson’s disease to the brain [5].

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References

  1. Stirpe P, Hoffman M, Badiali D, Colosimo C (2016) Constipation: An emerging risk factor for Parkinson's disease? Eur J Neurol 23: 1606-1613.
  2. Anderson G, Seo M, Berk M, Carvalho AF, Maes M (2016) Gut permeability and microbiota in Parkinson's Disease: Role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatoninergic pathways. Curr Pharm Des 22: 1381-1392.
  3. University of Iowa. "Parkinson's disease protection may begin in the gut." ScienceDaily.
  4. Pellegrini C, Colucci R, Antonioli L, Barocelli E, Ballabeni V, et al. (2016) Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models.
  5. Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, et al. (2015) Gut microbiota are related to Parkinson's disease and clinical phenotype. MovDisord 30: 350-358.