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Perspective - (2023) Volume 10, Issue 5

Glucosamine: Exploring Its Role in Joint Health, Benefits, and Controversies

Julian C. Knight*
Department of Orthopaedic Surgery, Queen Mary University London, United Kingdom
*Correspondence: Julian C. Knight, Department of Orthopaedic Surgery, Queen Mary University London, United Kingdom, Email:

Received: 08-Sep-2023, Manuscript No. ipar-23-14253; Editor assigned: 11-Sep-2023, Pre QC No. ipar-23-14253 (PQ); Reviewed: 26-Sep-2023, QC No. ipar-23-14253; Revised: 04-Oct-2023, Manuscript No. ipar-23-14253 (R); Published: 12-Oct-2023


In the realm of joint health, glucosamine has emerged as a popular dietary supplement. Its reputation as a natural remedy for joint pain and osteoarthritis has gained widespread attention. However, its efficacy, safety, and use have been subjects of debate among health professionals and researchers. This article aims to explore the role of glucosamine in joint health, its potential benefits, controversies, and the current understanding of its use.

Understanding glucosamine

Glucosamine is a natural compound found in the human body, primarily in the fluid surrounding joints. It is a building block for cartilage, the tough connective tissue that cushions the joints. Glucosamine supplements, typically derived from shellfish shells or produced synthetically, are available in various forms such as glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine.

The role of glucosamine in joint health

Glucosamine is believed to play a role in maintaining the integrity and health of cartilage. It is thought to help in the formation and repair of cartilage tissue and may have anti-inflammatory properties. Osteoarthritis, a degenerative joint disease characterized by the breakdown of cartilage, has been the focal point for glucosamine's potential benefits.


Benefits and effectiveness

Studies on the efficacy of glucosamine in managing osteoarthritis have yielded mixed results. Some research suggests that glucosamine supplements may alleviate joint pain and stiffness, improve function, and slow down the progression of osteoarthritis. However, other studies have not found substantial evidence supporting its effectiveness.

Controversies surrounding glucosamine

The efficacy of glucosamine has been a subject of debate due to conflicting study outcomes. Some studies have suggested that glucosamine supplements might not offer more significant significant benefits than a placebo. Additionally, questions have been raised about the quality and purity of supplements, and the absence of standardized regulations for glucosamine products.

Safety and side effects

Glucosamine is generally considered safe for most people. However, it can potentially interact with certain medications and may not be suitable for individuals with shellfish allergies. Side effects might include mild gastrointestinal symptoms, such as nausea, heartburn, and diarrhea. Long-term safety, especially at high doses, remains a topic for further investigation.

Dosage and forms of glucosamine

Glucosamine supplements come in various forms and dosages. Typical doses range from 500 mg to 1500 mg daily. It is available in oral tablet, capsule, or liquid form. Understanding the appropriate dosage and choosing a reliable brand should involve consultation with a healthcare provider.

Other uses and future research

Aside from joint health, glucosamine has also been explored for its potential in inflammatory bowel disease, temporomandibular joint disorders, and spinal disc degeneration. Further research is underway to clarify its role in these conditions and to gain a deeper understanding of its mechanisms of action.

Adverse effects and drug interactions

Glucosamine no matter what chondroitin raises the worldwide standardized proportion (INR) in people who are taking the blood slenderer, warfarin. It might likewise slow down the viability of chemotherapy for treating disease symptoms. Unfavorable impacts are gentle and rare and may incorporate stomach upset, clogging, loose bowels, migraine, and rash. Since glucosamine is generally gotten from the shells of shellfish, it could be dangerous for those with shellfish allergy. Numerous makers of glucosamine got from shellfish incorporate an admonition that those with a fish sensitivity ought to counsel a medical services proficient prior to taking the product. On the other hand, non-shellfish-inferred types of glucosamine are available. Another worry has been that the additional glucosamine could add to diabetes by disrupting the typical guideline of the hexosamine biosynthesis pathway, however a few examinations found no proof that this occurs. Different investigations led in lean or hefty subjects reasoned that oral glucosamine at standard portions doesn't influence insulin resistance.


Glucosamine remains a topic of interest in the field of joint health. While some studies suggest potential benefits in managing osteoarthritis, there is no conclusive evidence to fully support its widespread use. The decision to use glucosamine supplements should be made after consulting with a healthcare professional, considering individual health conditions and potential interactions. Ongoing research and continued scientific inquiry into glucosamine's efficacy and safety are essential in providing clearer guidance on its role in joint health.