Flyer

Molecular Enzymology and Drug Targets

  • Journal h-index: 5
  • Journal CiteScore: 0.46
  • Journal Impact Factor: 0.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
It Medical Team Scan Code
Google Scholar citation report
Citations : 54

Molecular Enzymology and Drug Targets received 54 citations as per Google Scholar report

Flyer image
Indexed In
  • China National Knowledge Infrastructure (CNKI)
  • Publons
  • Google Scholar
  • Secret Search Engine Labs
View More
Share This Page

Conference Proceeding - (2022) Volume 8, Issue 6

Knowledge Translation for Implementation of Point-of-Care Technology (POCT) in Breast Cancer Survivors in Africa: Descriptive study

Jean Paul Milambo1*, James Ndirangu1, Peter Nyasulu2, David Niyukuri3 and John Akudugu4
 
1Department of Public Health, Faculty of Health Sciences, University of Free State, South Africa
2Department of Global Health, Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
3Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
4Department of Public health, Faculty of Medicine and Health Sciences, University of Free State, South Africa
 
*Correspondence: Jean Paul Milambo, Department of Public Health, Faculty of Health Sciences, University of Free State, South Africa, Email:

Received: 01-Dec-2022, Manuscript No. Ipmedt-22-13288; Editor assigned: 05-Dec-2022, Pre QC No. Ipmedt-22-13288; Reviewed: 19-Dec-2022, QC No. Ipmedt-22-13288; Revised: 26-Dec-2022, Manuscript No. Ipmedt-22-13288; Published: 30-Dec-2022, DOI: 2572-5475- 08.06-117

Abstract

Background: Obesity and mediators of inflammation have been identified as the most important risk and predictive factors in postmenopausal breast cancer survivors (BCS) using aromatase inhibitors (AIs). Data is lacking on the effects of AIs on clinical, biomedical and genetic markers among postmenopausal BC women in the African settings.

Purpose: To assess the feasibility of HyBeacon probe genotyping adjunctive to standard care for timely prediction and diagnosis of AI-associated adverse events in breast cancer survivors in Africa.

Methods: Cross sectional study was conducted to assess the knowledge of POCT among six African countries using online survey and telephonically contacted. Incremental cost effectiveness ratio (ICER) was calculated, using diagnostic accuracy study. This was based on mathematical modeling.

Results: One hundred twenty-six participants were considered for analysis (mean age = 61 years; SD = 7.11 years; 95%CI: 60-62 years). Comparison of genotyping from HyBeacon probe technology to Sanger sequencing showed that sensitivity was reported at 99% (95% CI: 94.55% to 99.97%), specificity at 89.44% (95% CI: 87.25 to 91.38%), PPV at 51% (95%: 43.77 to 58.26%), and NPV at 99.88% (95% CI: 99.31 to 100.00%). Based on the mathematical model, the assumptions revealed that ICER was R7 044.55.

Conclusion:HyBeacon®probe genotyping for AI-associated adverse events is cost effective in Africa. The barriers for implementation of POCT application among six African countries for diagnosis of breast cancer included governance issues, insufficient awareness and insufficient trainings, lack of lab equipment’s, insufficient funding’s and ethical guidance issues for conducting genetic testing’s in African context.

Keywords

Unified fever definition; Blood flow; Temperature; Hyperthermia; Hypothermia; Heat energy

Citation: Milambo JP, Ndirangu J, Nyasulu P, Niyukuri D, Akudugu J (2021) Knowledge Translation for Implementation of Point-ofCare Technology (POCT) in Breast Cancer Survivors in Africa: Descriptive Study. Mol Enzy Drug Targ, Vol. 8 No. 6: 117.