Archives in Cancer Research

In this study, we simulated temperature distribution of DNA/RNA of human cancer cells when exposed to short pulses of Nd: YAG lasers. To end this goal, we considered a real three-dimensional (3D) geometry in which the total tissues of human cancer cells have been considered in the model. The time-dependent bio-heat equation has been used to calculate temperature distribution within the DNA/RNA of human cancer cells. The results show for spot size of ω=1.5 (mm), the energy of pulse can be increased to value of E = 0.5 (J) while the maximum of temperature DNA/RNA is 15°C. With this temperature for DNA/RNA of human cancer cells, the tissue is safe from thermal effect and its temperature exceeds rarely from 5°C to 10°C [1–19]. Furthermore, the time interval of temperature variations is less than 5 zeptosecond. In addition, Nd: YAG lasers must meet a number of criteria such as high reflection losses for highly reflecting mirrors or a well–defined transmission in certain wavelength range for output couplers and high optical quality include surface flatness, high roughness and also acceptable and reasonable resistance against high optical intensities. In this investigation, design and manufacturing of optical filters in Microwave, IR and UV–Vis regions for Nd: YAG lasers have been also studied. Moreover, effectiveness factors on laser damage threshold have been analysed and interesting results was obtained from this study (Figures 1–3).

Figure 1: Interaction between DNA/RNA of human cancer cells and Nd: YAG laser in Microwave region.

Figure 2: Interaction between DNA/RNA of human cancer cells and Nd: YAG laser in IR region.

Figure 3: Interaction between DNA/RNA of human cancer cells and Nd: YAG laser in UV–V is region.

References

1. Heidari A (2012) A thesis submitted to the Faculty of the Chemistry, California South University (CSU), Irvine, California, The United States of America (USA) in fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in chemistry.
2. HeidariA (2015) Simulation of interaction of light and iridium nanoparticles using 3D finite element method (FEM) as an optothermal cancer cells treatment. International Journal of Theoretical, Computational and Mathematical Chemistry 1: 11–16.
3. Heidari A, Brown C (2015) Study of composition and morphology of cadmium oxide (CdO) nanoparticles for eliminating cancer cells. Journal of Nanomedicine Research 2: 20.
4. Heidari A, Brown C (2015) Study of surface morphological, phytochemical and structural characteristics of rhodium (III) oxide (Rh2O3) nanoparticles. International Journal of Pharmacology. Phytochemistry and Ethnomedicine 1: 15-19.
5. Heidari A (2016) Anexperimental biospectroscopic study on seminal plasma in determination of semen quality for evaluation of male infertility. Int J AdvTechnol 7: e007.
6. A Heidari (2016) Extraction and pre-concentration of n-tolyl-sulfonyl-phosphoramid-saeure-dichloridas an anti-cancer Drug from Plants: A Pharmacognosy Study. J Pharmacogn Nat Prod 2: e103.
7. Heidari A (2016) A thermodynamic study on hydration and dehydration of DNA and RNA-Amphiphilecomplexes. J Bioeng Biomed Sci S: 006.
8. Heidari A (2016) Computational studies on molecular structures and carbonyl and ketene groups’- Effects of singlet and triplet energies of azidoketeneO=C=CH–NNN and isocyanatoketene O=C=CH–N=C=O. J ApplComputat Math 5: e142.
9. Heidari A (2016) Study of irradiations to enhance the induces the dissociation of hydrogen bonds between peptide chains and transition from helix structure to random coil structure using ATR–FTIR, Raman and 1HNMR spectroscopies. J Biomol Res Ther 5: e146.
10. Heidari A (2016) Future prospects of point fluorescence spectroscopy, fluorescence imaging and fluorescence endoscopy in photodynamic therapy (PDT) for cancer cells. J Bioanal Biomed 8:e135.
11. Heidari A (2016) Abio-spectroscopic study of DNA density and color role as determining factor for absorbed irradiation in cancer cells. Adv Cancer Prev 1: e102.
12. HeidariA (2016) Manufacturing process of solar cells using Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) nanoparticles. J BiotechnolBiomater 6: e125.
13. Heidari A (2016) Anti-cancer effect of uv irradiation at presence of Cadmium Oxide (CdO) nanoparticles on DNA of cancer cells: A photodynamic therapy study. Archives in Cancer Research 4: 61.
14. Heidari A (2016) Quantitative Structure–Activity Relationship (QSAR) Approximation for Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) nanoparticles as anti-cancer drugs for the catalytic formation of proviral DNA from Viral RNA using multiple linear and non-linear correlation approach. Annals of Clinical and Laboratory Research 4: 76.
15. A Heidari (2016) Ananalytical and computational infrared spectroscopic review of vibrational modes in nucleic acids. Austin J Anal Pharm Chem 3: 1058.
16. Heidari A (2016) Biochemical and pharmacodynamical study of microporous molecularly imprinted polymer selective for Vancomycin, Teicoplanin, Oritavancin, Telavancin and Dalbavancinbinding. BiochemPhysiol 5: e146.
17. Heidari A (2016) Anovel experimental and computational approach to photobiosimulation of telomericDNA/RNA: A biospectroscopic and photobiological study. J Res Development 4: 144.
18. Heidari A (2016) A combined computational and QM/MM molecular dynamics study on Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a–BNNTs) and Hexagonal Boron Nitride Nanotubes (h–BNNTs) as hydrogen storage, structural chemistry & crystallography communication 2: 18.
19. Heidari A, Brown C (2016) Phase, composition and morphology study and analysis of Os-Pd/HfCNanocomposites, Nano Research & Applications 2:14.