Journal of Biomedical Sciences

  • ISSN: 2254-609X
  • Journal h-index: 18
  • Journal CiteScore: 4.95
  • Journal Impact Factor: 4.78
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Euro Pub
  • Google Scholar
  • J-Gate
  • Secret Search Engine Labs
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Editorial - (2022) Volume 11, Issue 11

Study on the Repair and Remodelling of Cerebral Nerve in Children with Cerebral Palsy by Acupuncture

Ramya Radhakrishnan*
Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, Delhi, India
*Correspondence: Ramya Radhakrishnan, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, Delhi, India, Email:

Received: 01-Nov-2022, Manuscript No. IPJBS-22-13295; Editor assigned: 03-Nov-2022, Pre QC No. IPJBS-22-13295; Reviewed: 16-Nov-2022, QC No. IPJBS-22-13295; Revised: 21-Nov-2022, Manuscript No. IPJBS-22-13295; Published: 30-Nov-2022, DOI: 10.36648/2254- 609X.11.11.90


Objective: to find out how acupuncture affects motor development and brain plasticity in children with cerebral palsy. In young rats with cerebral palsy, investigate the effect on the mechanism of apoptosis of brain nerve cells, the regulation of the expression of neurotrophic factors, the promotion of the remodeling of nerve synaptic structure, and motor development. Two: To assess the impact and system of needle therapy on cerebral paralysis. Three: Acupuncture's effect on nerve repair in cerebral palsy.

Methods: 1078 cases of cerebral palsy and 146 cases of brain injury were included in this randomized controlled study using the ICF Gross motor function measure; Gesell, muscle tension, joint activity, and Activity of Daily Living; GMFM, Peabody's fine motor function, ADL, transcranial Doppler, TCD, skull B ultrasound, Brain Nuclear Magnetic Resonance Imaging MRI, Positron Emission Tomography SPECT, and the Diffusion Tensor Tractography (DTI) method of evaluation are all used to assess the brain.

Results: Transcranial Doppler, TCD total efficiency (79.3%) was significantly higher than that of the control group (51.8%), and the recovery rate of extracellular space was significantly higher than that of the control group (70.8%) (P 0.05). Acupuncture effectively reduces neurological sequelae by promoting neurological and cognitive movement development in infants younger than six months.

Conclusion: In children with cerebral palsy, acupuncture rehabilitation not only promotes the development of the white matter and gray matter, but it also promotes the remodeling and compensation of brain function, social adaptation, language and other cognitive function development, movement and recovery of fine motor function, and the children's ability to take care of themselves.


Cerebral palsy; Acupuncture; Nerve repair; Nerve recombination; Movement and Fine motor function; Cognitive function development


The types and severity of CP symptoms vary from person to person, and they may even change over time. Symptoms can vary widely from person to person, depending on which brain regions have been damaged [1, 2]. All people with cerebral palsy have issues with posture and movement, and some also have some intellectual disability, seizures, and other medical conditions.

Additionally, CP patients may have difficulties with language, speech, and vision or hearing. Although CP is the leading cause of childhood disabilities, not all of them are severe. While a child with severe CP may be unable to walk and require on-going, extensive care, a child with mild CP may only be slightly awkward and require no additional assistance. The disorder does not progress over time, which means that it does not get any worse. However, certain symptoms may become more or less apparent as the child gets older [3, 4]. The Centres for Disease Control and Prevention found that there is an average of 3.3 children with cerebral palsy for every 1,000 live births. Cerebral palsy cannot be cured, but a number of people can improve their motor skills and ability to communicate with the outside world with the assistance of supportive treatments, medications, and surgery.


The abnormal developments of a portion of the brain or damage to areas of the brain that control movement are the two main causes of cerebral palsy [5]. Before, during, or shortly after birth, this damage can occur. The majority of children have congenital cerebral palsy, or CP, which means that they were born with it. However, it can take months or years to find out that they have it. Only a small percentage of children are born with acquired cerebral palsy, which indicates that the condition begins at birth. Brain damage in the first few months or years of life, infections like bacterial meningitis or viral encephalitis, issues with blood flow to the brain, head injuries from a car accident, a fall, or child abuse are some of the causes of acquired cerebral palsy. The root cause of cerebral palsy is often a mystery [6]. Genetic abnormalities, brain malformations at birth, fevers or infections in the mother, or injury to the foetus are all possibilities.

Damage to the brain's white matter the white matter is the part of the brain that is in charge of sending messages to other parts of the body and inside the brain. The damage caused by PVL looks like tiny holes in an infant's brain's white matter. These holes in mind tissue disrupt the typical transmission of signs. Between 26 and 34 weeks of gestation, researchers have identified a period of selective vulnerability in the developing fetal brain in which the periventricular white matter is particularly vulnerable to insults and injury [7, 8].

Brain malformations that hinder the transmission of brain signals can result from any disruption of the normal process of brain growth that occurs during fetal development. During this early stage, mutations in genes that control brain development can prevent normal brain development. Contaminations, fevers, injury, or different circumstances that cause undesirable circumstances in the belly likewise put an unborn child's sensory system in danger [9, 10].


During the first two years of life, the majority of children with cerebral palsy are diagnosed. However, diagnosing a child before the age of 4 or 5 can be challenging if their symptoms are mild. The child's motor skills will be assessed by a series of tests ordered by doctors. The child's development, growth, muscle tone, age-appropriate motor control, hearing and vision, posture, and coordination will all be monitored by the doctor during regular visits to rule out other conditions that might cause similar symptoms. CP is not progressive, even though symptoms can change over time. A condition other than CP, such as a genetic or muscle disease, metabolism disorder, or tumours in the nervous system, is more likely to be the cause of a child's persistent loss of motor skills. Other conditions that may cause symptoms similar to those associated with CP can be identified through laboratory tests. An MRI scan or other neuroimaging procedure that allows doctors to look inside the brain can identify abnormalities that point to a movement disorder that may be treatable.



Conflict of Interest

Author declares No conflict of interest


  1. Nachega JB, Marconi VC, Gardner EM, Hong SY, Gross R, et al.  (2011) HIV treatment adherence, drug resistance, virologic failure: evolving concepts. Infect Disord Drug Targets 11: 167-174.
  2. Google Scholar, Crossref, Indexed at

  3. Nachega JB, Mills EJ, Schechter M (2010) Antiretroviral therapy adherence and retention in care in middle-income and low-income countries: current status of knowledge and research priorities. Current Opinion in HIV and AIDS 5: 70-77.
  4. Google Scholar, Crossref, Indexed at

  5. Burgoyne RW, Tan DH (2008) Prolongation and quality of life for HIV-infected adults treated with highly active antiretroviral therapy (HAART): a balancing act. J Antimicrob Chemother 61: 469-473.
  6. Google Scholar, Crossref, Indexed at

  7. Huang L, Cattamanchi A, Davis JL, den Boon S, Kovacs J, et al. (2011) HIV-associated Pneumocystis pneumonia. Proc Am Thorac Soc 8: 294-300.
  8. Google Scholar, Crossref, Indexed at

  9. Beck CR, McKenzie BC, Hashim AB, Harris RC, Zanuzdana A, et al. (2013) Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis. Influenza and Other Respiratory Viruses 7 Suppl 2: 72-75.
  10. Google Scholar, Crossref, Indexed at

  11. D'Herelle F (2007) on an invisible microbe antagonistic toward dysenteric bacilli: brief note by Mr F D'Herelle, presented, Mr Roux. Res Microbiol 158: 553-554.
  12. Google Scholar, Crossref, Indexed at

  13. Steinhardt E, Israeli C, Lambert RA (1913) Studies on the cultivation of the virus of vaccinia. J Infect Dis 13: 294-300.
  14. Google Scholar, Crossref, Indexed at

  15. Rosen FS (2004) Isolation of poliovirus-John Enders and the Nobel Prize. N Engl J Med 351: 1481-1483.
  16. Google Scholar, Crossref, Indexed at

  17. Stanley WM, Loring HS (1936) the Isolation of Crystalline Tobacco Mosaic Virus Protein from Diseased Tomato Plants. Science 83: 85.
  18. Google Scholar, Crossref, Indexed at

  19. Creager AN, Morgan GJ (2008) after the double helix: Rosalind Franklin's research on Tobacco mosaic virus. Isis 99: 239-272.
  20. Google Scholar, Crossref, Indexed at

Citation: Radhakrishnan R (2022) Study on the Repair and Remodelling of Cerebral Nerve in Children with Cerebral Palsy by Acupuncture. J Biomed Sci, Vol. 11 No. 11: 90