Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
Mini Review
DNA Repair Pathways are triggered to keep up Genetic Stability and Integrity
Author(s): Agostinho Machado
Cancer order instability arises from numerous defects in DNA-repair machinery,
that build cancer cells a lot of vulnerable to polymer targeting agents. The
interrelatedness between polymer repair deficiency and therefore the multiplied
impact of polymer targeting agents highlights the double-strand break (DSB)
repair that contains the homologous recombination (HR) and non-homologous
finish change of integrity (NHEJ) pathways. The polymer targeting agents area
unit classified into 2 major groups: non-covalent polymer binding agents and
valence DNA-reactive agents. Though these agents have well-known limitations,
like resistance and secondary carcinogenesis risk, they're very necessary in
today's real-life cancer medical care together with targeted medical care and
therapy. Indeed, polymer targeting medicine area unit promising medicine with
an exact app.. View More»
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