Molecular Enzymology and Drug Targets

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Substrate specificity

Certain enzymes bind to the certain substrates only. There are 4 types of specificity, they are absolute specificity, group specificity, linkage specificity and stereochemical speficity depending on their steric sites, number of reactions they undergo, groups, type of bond they form.

The substrate is relatively smaller than the enzyme. Therefore, the substrate is binding with a portion of the enzyme. The substrate is attached to the enzyme with weak bonding forces such as hydrogen bond, electrostatic interactions, and dipole-dipole interactions. The substrates are usually complementary to the enzymes. However, it is possible that they do not fit perfectly each other. These bonding forces help the complex to be more stable. In the case of two substrate reactions involving ternary complex, two substrates must be bound close to each other to precede the reaction. It is impossible to proceed the reaction if two substrates are not adjacent or close each other spatially. From the case, the enzyme should have some steric specificity.

Related Journals of Substrate specificity

Biochemistry & Molecular Biology Journal, Biochemistry & Analytical Biochemistry,Advances in Biological Regulation,Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology,Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology,Current Enzyme Inhibition,Enzyme and Microbial Technology,Enzyme Research