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International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 38
  • Journal CiteScore: 46.78
  • Journal Impact Factor: 1.95
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Abstract

A Convergent Synthetic Platform for Nanoparticle with Combination against Visceral Leishmaniasis

Prachi Sharma and Swati Gupta

The synthesis of PLGA-Nanoparticles therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a difficult challenge in drug delivery and polymer chemistry. Herein, we report the synthesis of PLGA-Nanoparticles that carry accurate weight ratios of Amphotericin B and Doxorubicin. To our knowledge, this work provides the example of macrophage targeted therapy against visceral leishmaniasis by incorporating macrophage specific ligand-Lectin which specifically targets to the localized target sites. The highly convergent synthetic approach opens the door to new Nanoparticles based combination therapies for visceral leishmaniasis.