International Journal of Drug Development and Research

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A Convergent Synthetic Platform for Nanoparticle with Combination against Visceral Leishmaniasis

Prachi Sharma and Swati Gupta

The synthesis of PLGA-Nanoparticles therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a difficult challenge in drug delivery and polymer chemistry. Herein, we report the synthesis of PLGA-Nanoparticles that carry accurate weight ratios of Amphotericin B and Doxorubicin. To our knowledge, this work provides the example of macrophage targeted therapy against visceral leishmaniasis by incorporating macrophage specific ligand-Lectin which specifically targets to the localized target sites. The highly convergent synthetic approach opens the door to new Nanoparticles based combination therapies for visceral leishmaniasis.