S Prem Mathi Maran
A new method, which is patented, is developed to reinforce the bio availability of fresh tea leaves to extract gallate catechins, an anti-malarial drug. The tactic involves use of a patented hydrodynamic system which converts the fresh tea leaves into a nano emulsion. This active catechins rich Nano emulsion is filtered and clear emulsion is collected. This clear emulsion is subjected to liquid-liquid extraction and therefore the catechins are isolated through a solvent phase. Then the solvent phase is dried during a molecular distillation unit and subsequently during a vacuum tray drier to urge a green colored powder. The HPLC analysis revealed that this extract has all the eight catechins in higher levels and its bioavailability is increased to 10-fold as compared to the commercially available tea extracts.
The present paper comprehensively reviews the mechanisms resulting in low absorption, poor permeability and fewer stability of tea catechins and also describes the potential for improving the bioavailability of tea catechins through new techniques like nanoparticle-based delivery systems, structurally modified molecule of catechins, co-administration with other drugs or bioactive. Furthermore, the challenges and future research directions also are discussed. To gather the related references, computerized systematic literature searches were conducted in web of Science and Google Scholar databases to retrieve the pertinent studies and reviews. The papers published within the English language were exclusively evaluated. No other limitations were applied. The particular catchphrases used were tea catechins or tea polyphenols or with the terms retaining, bioavailability, assimilation, or nanoparticles, prodrugs, per acetylate, and synergistic also in light of the fact that the terms improvement and overhaul. First, into a discussion on the bioavailability of catechins, and then, to supply more thorough insights into the way and mechanism to enhance.