Journal of Universal Surgery

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A Rarity in Breast Disease: Metastatic Ovarian Carcinoma to the Breast Mimicking Inflammatory Breast Cancer

Ben Fauzi El Attrache, Camryn Highsmith, Bradley Gluck, Alan Heimann and Edna Kapenhas

Metastatic ovarian carcinoma to the breast has been documented in 110 cases with an incidence of <1%. Infrequently this can mimic inflammatory breast carcinoma making differentiation between breast and ovarian cancer challenging. Immunohistochemistry (IHC) markers like paired box gene 8 (PAX8) positivity, Wilms’ tumor 1 (WT1) positivity, and gross cystic disease fluid protein 15 (GCDFP-15) negativity, however, can allow for diagnostic certainty. With only seven other cases of metastatic ovarian carcinoma mimicking inflammatory breast cancer, this case is an exceptional and unique find. The patient in this study presented with three months of left breast edema and erythema. Skin biopsies were performed to assess for inflammatory breast cancer. With her recent diagnosis of metastatic ovarian cancer to the breast, metastatic disease was high on the differential. The histopathology results and immunohistochemistry had confirmed the diagnosis