Mitochondria, critical for cellular energy production, contribute to cancer progression by promoting glycolysis even in oxygen-rich conditions, a hallmark of the Warburg effect. This metabolic reprogramming enables cancer cells to maintain an alkaline intracellular pH and the acidic Tumor Microenvironment (TME), fostering tumor growth, immune evasion and therapy resistance. Alkalinization therapy, primarily through dietary interventions, neutralizes the acidic TME to enhance cancer treatment efficacy. By consuming low Potential Renal Acid Load (PRAL) foods and alkalizing agents, systemic acidity is reduced, with urine pH serving as a practical biomarker.
Published Date: 2025-02-19; Received Date: 2025-01-20
