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Abstract

Antigen Rapid Test is Expected to Accelerate the Detection Efficiency of the COVID-19 Epidemic

Zhang Lei, Yang Feng, Zhu Junzhe

Objective: Explore the performance and strength & weakness of antigen rapid test methods in detecting COVID-19 epidemic.

Methods: Selected 7 different companies’ antigen rapid test (nasal swab) product test data for comparison and the clinical results (sensitivity, specificity and accuracy) of each company's swab rapid antigen test product are obtained. Different onset time samples were tested with RT-PCR and COVID-19 antigen tests. Total 421 specimens were used in clinical study and the research will respect the autonomy of participants and conducts follow-up assessment of the rapid test to determine whether the COVID-19 is associated with the results. The sample used for rapid detection of COVID-19 antigen was nasal swab.

Results: Through clinical research show that the detection rate of COVID-19 antigen was decreased gradually, it was corresponding to the nature of antigen in the human body.

Conclusion: The emergence of various COVID-19 rapid tests (especially nasal swab) enables health professional to complete the preliminary screening. Antigen detection method has own advantages in COVID-19 epidemic. In antigen detection, we use products of different companies (Abbott, Roche, Healgen, Acro, Siemens, Lepu, Wondfo) to predict the advantages of convenient and sample collection, high throughput, low workload, high reproducibility and low cost in practical applications.