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Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Kamal A Ahmed, Salah A Elmahadi, Alneil M Hamza, Abdalla E Ali

Background: Hyperprolactinemia is the most prevalent endocrine disorder in hypothalamic- pituitary axis especially among reproductive age women. This cross section study was conducted to assess thyroid function among infertile Sudanese female with hyperprolactinemia.

Methods: One hundred infertile Sudanese females with hyperprolactinemia were chosen for this study and 50 infertile Sudanese females with normal prolactin level were used as controls. All individuals were within the same age group (16-42). Prolactin, LH, FSH, TSH, T4 and T3 were measured in both group by Radioimmunoassay.

Results: 17% of hyperprolactinemic patients were found to be with hypothyroid; interestingly no case was reported to have hypothyroidism or other thyroid dysfunction in the control group. The concentrations of serum PRL and TSH was significantly higher than in the control group while the level of LH and FSH were found to be significantly lower than in the control positive association was found between PRL and TSH among hyperprolactinemic patients.

Conclusions: This study was found an association between hyperprolactinemia and hypothyroidism. The relatively high occurrence of hypothyroidism among hyperprolactemic infertile females emphasizes the importance of estimating both serum prolactin and TSH in infertility.