Translational Biomedicine

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Bone Metastasis with Histology Different from The Primary Lung Cancer and The Skin Metastasis

Moldvay Judit, Szallasi Zoltan, Puskas Rita, Komaromi Tamas, Fabian Katalin, Kovalszky Ilona, Papay Judit

Introduction: It has already been reported in many types of malignant tumors that a solid metastasis can have a different histology and more aggressive state than the primary tumor.

Case presentation: We report the case of a 60-year-old smoker woman who presented with bone metastasis that histologically proved to be an adenocarcinoma. Bronchoscopy revealed a squamous cell lung cancer that – despite the different histology – was regarded as the primary tumor. Two weeks later a rapidly growing skin tumor developed that was also a squamous cell carcinoma, and was regarded as the distant metastasis of the endobronchial cancer.

Conclusions: In lung cancer it is important not to exclude the possibility of tumor dissemination even if the suspected primary tumor and the distant metastasis have different histologies.