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Farmacologia y Toxicologia

  • ISSN: 2174-8365
  • Journal h-index: 1
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • OCLC- WorldCat
  • Euro Pub
  • SHERPA ROMEO
  • International Committee of Medical Journal Editors (ICMJE)
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Abstract

Characterizing emerging blood-based biomarkers associated with inflammageing and metaflammation: implications for geroscience-guided clinical trials

Matthew Schenk

The global syndemic of aging and obesity is characterized by chronic, low-grade, systemic, sterile inflammation dubbed ‘inflammaging’ and ‘metaflammation’, respectively. Biomarkers representing dysregulated metabolic and immune-inflammatory phenotypes may serve as early predictors of age-related diseases and surrogate endpoints in intervention trials designed to increased human healthspan. However, the planning of large-scale human studies employing biomarker measurements requires careful assessment of the feasibility and reliability of said measurements. Interestingly, the geroscience hypothesis links the biology of aging with age-related diseases, suggesting that therapies that improve the pillars of aging can improve multiple diseases in parallel. As such, biomarkers of aging are known to associate with multiple age-related diseases.