Chronic osteomyelitis is a severe pathology that is often troublesome for physicians to manage. This condition requires both aggressive surgical and pharmacological approaches to eradicate the infection. Infrequently in adults, septic arthritis may manifest as a result of adjacent osteomyelitis. We present the first case of osteomyelitis along with secondary septic arthritis caused by Cupriavidus pauculus. A 28-year-old immunosuppressed female on hemodialysis presented with osteomyelitis of her right distal tibia and talar dome with subsequent septic arthritis of the tibiotalar joint. The distal tibia and superior talus were resected, antibiotic loaded cement was incorporated into the debrided area, and the spacer was internally fixed. Our patient is now undergoing a physical therapy regimen and has not experienced complications.