Pradeepa R* and Padmapreetha J
The aim of the present work is to design and development of the liquisolid compact of gingerol loaded lozenges. The objective of this study was to increase the solubility of poorly soluble drug gingerol. The formulation characterized for drug-excipients interaction using FTIR, DSC, XRD, drug content. The drug content was also above 97.82% for the optimized formulation. The development lozenges formulation, were optimized based upon the evaluation parameters such as weight variation, hardness, friability and drug content. From the results of above evaluation studies, formulation F4 was optimized. In vitro drug release of formulation F4 had exhibit release profile of 90.08% and it had followed Higuchi model. The stability studies of the optimized formulation LF4 was also found to be satisfactory. So, this technique was to improve the aqueous solubility and bioavailability of the active ingredient.
Published Date: 2025-01-03; Received Date: 2023-08-30
