International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page


Drug Absorption and Metabolism: Understanding the Journey of Medications inside the Body

Dr. Rajkumar Subramanian*

Drug absorption and metabolism are crucial processes that determine the efficacy and safety of drugs in the human body. The absorption of drugs depends on their physicochemical properties, such as solubility, lipophilicity, and molecular size, as well as the characteristics of the gastrointestinal tract, such as pH, motility, and permeability. Once absorbed, drugs undergo biotransformation by various enzymes, predominantly in the liver, to generate metabolites that are either inactive or active, and can be eliminated through the kidneys or bile. The metabolic fate of drugs can be influenced by genetic variations, drug-drug interactions, and disease states, leading to interindividual variability in drug response and toxicity. Understanding the mechanisms of drug absorption and metabolism is crucial for optimizing drug design and dosing, predicting drug-drug interactions, and minimizing adverse drug reactions.

Drug absorption and metabolism are complex processes that involve numerous factors and interactions. The physicochemical properties of drugs determine their ability to cross biological barriers, such as the intestinal epithelium or the blood-brain barrier, and reach their target site of action. For example, drugs that are hydrophilic and have a high molecular weight may have limited absorption, while those that are lipophilic and have a low molecular weight may be rapidly absorbed.


Drug absorption; Metabolism; Drug Development; Complex processes; Biological barriers

Published Date: 2023-05-29; Received Date: 2023-05-01