International Journal of Drug Development and Research

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Dr. Rajkumar Subramanian

Drug Metabolism and Pharmacokinetics, Suven Life Sciences Limited, Hyderabad, India

  • Research Article   
    Drug Absorption and Metabolism: Understanding the Journey of Medications inside the Body
    Author(s): Dr. Rajkumar Subramanian*

    Drug absorption and metabolism are crucial processes that determine the efficacy and safety of drugs in the human body. The absorption of drugs depends on their physicochemical properties, such as solubility, lipophilicity, and molecular size, as well as the characteristics of the gastrointestinal tract, such as pH, motility, and permeability. Once absorbed, drugs undergo biotransformation by various enzymes, predominantly in the liver, to generate metabolites that are either inactive or active, and can be eliminated through the kidneys or bile. The metabolic fate of drugs can be influenced by genetic variations, drug-drug interactions, and disease states, leading to interindividual variability in drug response and toxicity. Understanding the mechanisms of drug absorption and metabolism is crucial for optimizing drug design and dosing, predicting dr.. View More»

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