Farmacologia y Toxicologia

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Effect of omeprazole, pantoprazole and famotidine on rat bones

Dina Salem, Elhamy El-Kholy, Hala Abdel Malak, Abdelhadi M Shebl and Mahmoud Abdalla

Osteoporosis is the most common age-related skeletal chronic disorder. The use of acid-suppressive drugs (especially: proton pump inhibitors; PPIs and H2 receptor blockers; H2RAs) is widespread in osteoporotic patients. to counteract inflammation and ulceration of esophagus and stomach caused by prolonged use of anti-resorptive medications bisphosphonates especially fracture risk While, others have not observed any fracture risk with the use of PPIs . The data on the effects of H2RAs are conflicting too.
These drugs can reduce gastric acid secretion by up to 98% , irreversibly deactivating the proton pump (H+/K+ ATPase) of the gastric parietal cells. H2RAs (cimetidine, ranitidine, famotidine) competitively inhibit H2 receptors, have similar effects to PPIs, although they are less potent, blocking only 70% of gastric acid production . It has been suggested a possible association between gastric acid suppressants and increased hip, spine, and any-site fractures risk has been found in previous studies. Several mechanisms of this association have been proposed in theory, such as the possibility that PPIs decrease calcium-absorption, leading to bone mineral density (BMD) loss or they decrease magnesium absorption, which is important to bone health, other studies suggest that these agents can cause hyperparathyroidism by acid suppression and lead to decrease in BMD. Best YouTube to MP3 converter. Download MP3 from YouTube for Free. one would honestly have expected more on the track Youtube to mp3 Download Mp3 songs for free Given the legendary pedigree of the man behind the sound Download mp3 songs online at Mp3 Converter, watch high quality online music videos watch and download free songs of the highest quality. Listen to songs online here comfortably without any annoying advertisements. Easy to use and free MP3 downloader. YouTube To MP3 download in seconds using the best YouTube to MP3 converter. YouTube To Mp3 Get the latest song by simply typing the latest artist or song title in the Search menu. Mp3 file format with 128 - 320 Kbps bitrate converted from YouTube videos. read at this blog All those artist performances are still available on YouTube today find more here