Archives of Medicine

  • ISSN: 1989-5216
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Effects of insulin on ADPN and AdipoR1 in diabetic rats


In this study, we have investigated insulin resistance (IR), plasma adiponection (ADPN) and ADPN receptors (AdipoR) expression in high-fat (HF) diet fed (8 weeks) rats with or without streptozotocin (STZ) treatment (30 mg/kg i.p.). Our results show that HF diet either alone or in combination with STZ treatment decreased plasma levels of ADPN and expression of muscle AdipoR. These disorders were improved with insu- lin (INS) treatment (1 IU/kg i.p.). In conclusion, our results suggest that ADPN might play an important role in amelioration of IR in these experimental model of type 2 diabetes.