Ethiopia is a country characterized by a wide range of climate and ecological condition which helped to have high diversity of medicinal plants and up to 80% of the population use traditional medicine for primary health care. Studies on the current practices of the communities in the area are vital to document the basic information in these regars. Therefore, this study was aimed in assessing the practices of traditional plant medicine use among communities of Wonchi District. The most widely used route of administration in the study area was oral accounted for (56.67%) followed by dermal (29.63%) This is the reason that oral and dermal routes permit rapid physiological reaction of the prepared medicines with the pathogens and increase its curative power. The prepared traditional medicines were applied in a number of ways, among which drinking (37.57%), creaming (16.76%), and eating (10.40%) were mentioned frequently.