Translational Biomedicine

  • ISSN: 2172-0479
  • Journal h-index: 18
  • Journal CiteScore: 5.91
  • Journal Impact Factor: 4.11
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • ResearchBible
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Publons
  • MIAR
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page


Evaluation of Alpha One Anti-Trypsin and Haptoglobin in Hypertensive Patients in Elele

Nnatuanya IN, Obeagu EI*, Nnatuanya CIC, Ogar OA, Stephen EC and Onah A

Inflammation is associated with different cardiovascular diseases like in hypertension. This study to evaluate the level of alpha one anti-trypsin (AAT) and haptoglobin in hypertension was carried out on patients attending Madonna University Hospital (MUTH), Elele, Rivers State, Nigeria. The research was done on a total of one hundred (100) subjects. Fifty (50) of this population were hypertensive patients (Test) while fifty (50) were the control. Their age ranged from 45-65 years. Alpha one anti-trypsin and haptoglobin were measured by Mispa Auto-analyzer Nephelometric immunoassay method. The results were analyzed using statistical package for social science (SPSS) version 20. The results showed a significant increase (P<0.05) in haptoglobin in hypertensive subjects (120.9 ± 54.90 mg/dl) when compared with the control (47.7 ± 32.61 mg/dl). Haptoglobin was elevated in hypertension. Hence, level of haptoglobin could be used to predict cardiovascular risk in patients with certain disease conditions. The results also showed significant increase (P<0.05) in the AAT level of hypertensive subjects (293.7 ± 59.86 mg/dl) compared to the control (158.8 ± 52.14 mg/dl) respectively. Alpha one anti-trypsin plays a role as a biomarker in hypertension.