International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 51
  • Journal CiteScore: 46.50
  • Journal Impact Factor: 26.99
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page


Hepatoprotective activity of Clerodendron Inerme against Paracetamol induced Hepatic injury in Rats for Pharmaceutical Product

*Haque Rabiul, Mondal Subhasish, Sarmita Sinha,Modhurupa Ghose Roy, Devlina Sinha, Sunita Gupta

Hepatitis is one of the major health problems in human which sometimes may lead to even death. Natural products may be the best source of remedies for the treatment of liver diseases. Thus identification of a potential therapeutic agent for the protection of liver from the hepatotoxins will provide a useful way for the prevention of these liver related illnesses. Our studies identified a plant with potential hepatoprotective activity. The etanolic extract of Clerodendron inerme leaves were screened for its hepatoprotective activity in paracetamol induced liver damage in Swiss albino rats at a dose of 200 mg/kg bw. The etanolic extract exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bilirubin. Liv.52 was used as positive control. The effects of the drug was judged by changes in serum marker ALT, AST, ALP, Protein and bilirubin levels. The extract did not show any mortality up to a dose of 2000g/kg bw.