Among the various helminthic parasites infecting humans Stongyloides steroralis assumes a special status due to its versatile life cycle and its potential to cause acute to chronic and disseminated infections. Strongyloidiasis can turn out to be a life threatening infection among individuals with compromised immune system. Another interesting phenomenon with human strongyloidiasis is the association of S stercoralis infection and it’s Pathophysiology with co-morbid conditions like tuberculosis and HIV infection prevalent in the endemic regions. Recent studies have demonstrated the influence of strongyloidiasis on CD+ T cell immune responses. There is only less literature available on the epidemiology of strongyloidiasis throughout the world undermining its pathogenic potential. The present manuscript attempts to review and update both clinicians and clinical microbiologists about human stongyloidiasis.