Neuro-inflammation is a key component in the ischaemic cascade following cerebral ischaemic insult that results into tissue damage, leakage in the bloodbrain barrier and death in the sub-acute phase. Failure of anti-inflammatory drugs to improve outcome in clinical settings have suggested its response following an ischeamic attack is detrimental. Hypothermia is a robust neuro protectant and has consistently shown benefit against a variety of brain injuries at the experimental level. It has recently been shown to improve neurological outcome in comatose survivors of cardiac arrest and neonatal hypoxic ischemia. Although until now, therapeutic hypothermia doesn’t categorise under any therapeutic standards of parameters, but it is well accepted that cooling should be started as soon as possible following an ischeamic attack. This review discusses the protective influence of hypothermia on the neuro-inflammatory response.
Published Date: 2022-03-03; Received Date: 2022-01-16