Annals of Clinical and Laboratory Research

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IgA-IgA Biclonal Gammopathy of Undetermined Significance: A Case Report and Review of the Literature

Ibtissam MHIRIG*, Sara Harrar, Ayoub Bouchehboun, Saliha Chellak and Abderrahman Boukhira

Biclonal gammopathy is a rare disease entity characterized by the simultaneous appearance of two bands, at different positions, on the Serum Protein Electrophoresis (SPEP) and serum immunofixation electrophoresis (SIFE), resulting from the clonal expansion of two dissimilar neoplastic cell lines. We report a case of a biclonal gammopathy of undetermined significance. SPEP showed a biclonal appearance in the gamma region. SIFE confirmed the presence of an IgA-IgA double band. This combination of heavy chains is rarely described in the literature.

Published Date: 2022-02-14; Received Date: 2021-12-15