Journal of Universal Surgery

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Is the Presence of Single or Multiple Gallstones a Matter of Chance? What is the Relationship between the Number of Stones and Lipid Profile, Age, Gender, and Stone Type?

Sebahattin Elika

We aimed to investigate the effect of lipid profile, age, type of stone, and gender on the number of gallstones. Methods: The single-center, prospective studies included 177 patients with cholelitiasis. Of these, 59 patients were excluded from the study, including the ones who had no pathology, the ones detected with biliary sludge and polyps, the ones taking antidiabetic and antilipidemic drugs, and the ones detected with acute cholelitiasis. As a result, 118 patients were included into the study. Age, gender, and lipid profile (total cholesterol, low-density lipoprotein [LDL], highdensity lipoprotein [HDL], and very low-density lipoprotein [VLDL]) were recorded. Numbers of stones (single or multiple) were analyzed by single variable analysis using student-t test, Chi-square test, Fisher’s-exact test and Mann-Whitney U test, as appropriate. In multivariate analysis, the logistic regression test was used for the prediction of the number of stones (single or multiple) by using the probability factors defined by earlier studies.