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Nivolumab and Acute Grade III Renal Toxicity

Michael Vaslamatzis, Theodoros Tegos, Natalia Asimakopoulou, Theodora Ikonomaki, Vassiliki Nikolaidou, ChristinaDanai Skondra, Stavros Pantelakos, Konstantinos Kotsifas, Konstantina Karagiorgou, Konstantinos Folinas, George Karkaletsos, Aleksandra Tsirogianni, Charalampos Zoumplios, Christina Vourlakou3 and Nektarios Alevizopoulos

Background: Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies that changed the treatment of cancer and improved the patient’s outcome. However these agents are associated with several "immune-mediated" adverse effects, of which, acute kidney injury (AKI) is quite rare.

Case report: A 58-year old patient diagnosed with advanced NOS/NSCLC, and not receiving any other medication, experienced a decline in the renal function after four cycles with nivolumab. After ruling out other common causes of interstitial nephritis, was attributed as a cause of interstitial nephritis, confirmed by the renal biopsy. The patient discontinued immunotherapy and he was treated with intravenous prednisolone. There was a slight decrease in creatinine values and he continued treatment at home. Two months later creatinine values had returned to normal, but unfortunately, the patient died from an acute heart attack.

Conclusions: AKI is a possible but rare complication of immunotherapy which may require discontinuation of ICPIs and corticosteroid treatment. Best YouTube to MP3 converter. Download MP3 from YouTube for Free. one would honestly have expected more on the track Youtube to mp3 Download Mp3 songs for free Given the legendary pedigree of the man behind the sound Download mp3 songs online at Mp3 Converter, watch high quality online music videos watch and download free songs of the highest quality. Listen to songs online here comfortably without any annoying advertisements. Easy to use and free MP3 downloader. YouTube To MP3 download in seconds using the best YouTube to MP3 converter. YouTube To Mp3 Get the latest song by simply typing the latest artist or song title in the Search menu. Mp3 file format with 128 - 320 Kbps bitrate converted from YouTube videos. read at this blog All those artist performances are still available on YouTube today find more here