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Farmacologia y Toxicologia

  • ISSN: 2174-8365
  • Journal h-index: 1
  • Average acceptance to publication time (5-7 days)
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Abstract

Parkinson's disease

Ebru Kuyumcu Savan

Parkinson's disease (PD) is a complex neurodegenerative age-related disease associated with loss of dopaminergic cells and both motor and non-motor disorders. PD is the second most common neurodegenerative disease that affects above 85 years of age and affects 2% of the population over 60 years of age. PD is the brain's reward that causes typical motor symptoms such as tremor, bradykinesia, rigidity, contraction, as well as non-motor symptoms such as executive dysfunction, mood and sleep disturbance, with constant loss of dopaminergic neurons in the substantia nigra (black substance) of the midbrain. It is defined as a disease caused by dopamine deficiency, a neurotransmitter that helps control learning and emotional centers [1-4].