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Molecular Enzymology and Drug Targets

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Abstract

Prediction of Epitope and Host Organism for Generation of Antibodies against Human Toll-Like Receptor 5 Protein

Kulwant Solanki,Jitender Yadav,Ravinder Singh,Smita Rastogi Verma

Toll-like receptors (TLRs) are transmembrane proteins that help in the recognition of pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate the activation of signaling pathways invoking immune and inflammatory responses for their destruction. These receptors are highly conserved in eukaryotes and share similarities at structural and functional levels. Among TLRs, TLR5 is the receptor for flagellin, a major constituent of bacterial flagella and a virulence factor