Journal of Biomedical Sciences

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Protective Role of Virgin Coconut Oil against Adverse Effects of Atrazine Toxicity on Glucose and Oestradiol Metabolism in Male Wistar Rats

Titilope Helen Olatunbosun1*,Elemi John Ani2, Uyai Edidiong Francis1 ,Asuquo Etim Asuquo1, Department of Physi1

This study assessed protective role of Virgin Coconut Oil (VCO) following atrazine- induced glucose metabolic derangement in rats. Adult male albino wistar rats weighing 180-200 g body weight were used for the study. They were randomly separated into two major experimental groups (The test and recovery groups). Treatment in the test group lasted for 2 weeks, after which the animals were sacrificed and blood collected for analysis and treatment in the recovery group lasted for four weeks. In the test groups, the results of this study on glucose metabolism showed that Diabetes and Atrazine (ATZ) significantly increased (p<0.05) the fasting blood glucose level and reduced serum estradiol levels. In conclusion, Atrazine (ATZ) toxicity deranged glucose metabolism but the withdrawal of Atrazine (ATZ) significantly reversed some of these derangements; with more pronounced effect following Virgin Coconut Oil (VCO) administration.