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Translational Biomedicine

  • ISSN: 2172-0479
  • Journal h-index: 12
  • Journal CiteScore: 8.06
  • Journal Impact Factor: 1.0
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Abstract

The Cell-Free Mitochondrial DNA: A Novel Biomarker of Cardiovascular Risk?

Alexander E Berezin

Circulating cell-free mitochondrial DNA could find in healthy subjects and patients with neoplasia, trauma, infections, stroke, autoimmune, metabolic and rheumatic diseases. The triggers of cell-free mitochondrial DNA secretion are various impacts, i.e. microbial antigen stimulation, inflammatory cytokine, active molecules. It is speculated that the cell-free mitochondrial DNA might be a critical activator of inflammation, coagulation and the innate immune system linking mitochondrial dysfunction, cell death and target organ injury. There is evidence regarding that the cell-free mitochondrial DNA levels may elevate in healthy individuals depending aging and in cancer and non-cancer subjects at risk of CV diseases, as well as in persons with established CH disease. The results of several studies have shown that elevated circulating cell-free mitochondrial DNA has associated with cardiovascular (CV) diseases, while diagnostic and predictive value of this biomarker in non-cancer individuals is not fully clear. The mini review is devoted the biological role, diagnostic and predictive value of cellfree mitochondrial DNA in patients at CV risk.