Translational Biomedicine

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The Erythropoietin Effect on Uterus Congestion after Uterine Ischemia Reperfusion

Tsompos C, Panoulis C, Toutouzas K, Triantafyllou A, Zografos G and Papalois A

Objective: This experiment investigated the erythropoietin (Epo) effect after uterine ischemiareperfusion (IR) in rats. The effect of Epo was evaluated studying the mean uterine congestion (UC) lesions. Materials and methods: The mean weight of 40 rats used in the study was 247.7 g. The UC lesions were estimated for the groups A and C on 60 min and for the groups B and D on 120 min after reperfusion. Only the groups C and D were administered by Epo.

Results: Epo administration non-significantly declined the UC lesions scores by (without lesions) 0.15 (-0.5595137-0.2595137) (p=0.4545). Reperfusion time non-significantly raised the UC lesions scores by (without lesions) 0.15 (-0.5676974-0.3676974) (P=0.5058). However, the combined Epo administration with reperfusion time non-significantly declined the UC lesions scores by (without lesions) 0.0090909 (-0.2577992-0.2396174) (p=0.9414).

Conclusions: The Epo administration presented a nonsignificantly declining short-term effect on UC lesions scores. Perhaps, a higher Epo dosage and/or an experimental time lasting longer than 2 hours may reveal more significant efficacies.