Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 38
  • Journal CiteScore: 46.78
  • Journal Impact Factor: 1.95
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
  • ResearchGate
Share This Page

Abstract

The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Immune Response Regarding Hepatitis C

Cosmin Constantin Oprea*

Purpose of review

Hepatitis C virus infection and the immune response in babies and adults.

Findings

The presence of MDSCs in new-borns makes Hepatitis C chronic in the first years of life in the case of exposure to virus. The expansion of MDSCs allows the immune system to maintain the chronic infection with Hepatitis C because MDSCs are responsible for the disfunction of the immune system and not the virus itself. MDSCs express CTLA-4, who is a protein receptor that functions as an immune checkpoint and down-regulates immune responses. The expression of the CTLA-4 protein in the lymph node allows the manifestation of hepatitis C and allows the inhibition of T cells against HCV RNA.

Summary

MDSCs are responsible for chronic Hepatitis C infection. The expansion of MDSC is the format in which hepatitis C manages to escape the immune system’s response. Inhibitory protein CTLA-4 expressed by MDSCs in lymph node maintain hepatitis C infection. MDSCs cells have the ability to interact with these signals generated by common progenitor lymphoid cells and in this way the immune system cannot exercise its function.

Published Date: 2021-07-30; Received Date: 2021-07-09