Independent Research, Bucharest, Romania
Short Communication
The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Immune Response Regarding Hepatitis C
Author(s): Cosmin Constantin Oprea*
Purpose of review
Hepatitis C virus infection and the immune response in babies and adults.
Findings
The presence of MDSCs in new-borns makes Hepatitis C chronic in the first years of life in the case of exposure to virus. The expansion of MDSCs allows the immune system to maintain the chronic infection with Hepatitis C because MDSCs are responsible for the disfunction of the immune system and not the virus itself. MDSCs express CTLA-4, who is a protein receptor that functions as an immune checkpoint and down-regulates immune responses. The expression of the CTLA-4 protein in the lymph node allows the manifestation of hepatitis C and allows the inhibition of T cells against HCV RNA.
Summary
MDSCs are responsible for chronic Hepatitis C infection. The expansion of MDSC is the format in .. View More»
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