International Journal of Drug Development and Research

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Cosmin Constantin Oprea

Independent Research, Bucharest, Romania

  • Short Communication   
    The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Immune Response Regarding Hepatitis C
    Author(s): Cosmin Constantin Oprea*

    Purpose of review Hepatitis C virus infection and the immune response in babies and adults. Findings The presence of MDSCs in new-borns makes Hepatitis C chronic in the first years of life in the case of exposure to virus. The expansion of MDSCs allows the immune system to maintain the chronic infection with Hepatitis C because MDSCs are responsible for the disfunction of the immune system and not the virus itself. MDSCs express CTLA-4, who is a protein receptor that functions as an immune checkpoint and down-regulates immune responses. The expression of the CTLA-4 protein in the lymph node allows the manifestation of hepatitis C and allows the inhibition of T cells against HCV RNA. Summary MDSCs are responsible for chronic Hepatitis C infection. The expansion of MDSC is the format in .. Read More»

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