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The Systematic Review and Implications of Organoid Technology

Giovana Macedo Egídio Cavalcante, Taysa Leite de Aquino, Jaiany Rodrigues Libório, Dara Fernanda Brito Duarte, Juliana Oliveira Duarte Rebouças, Eugenia Machado Couto, Pablo de Oliveira Saraiva Bezerra, Gabriela Macedo Egidio Cavalcante, Maria Águeda Brito Leite Duarte, and Modesto Leite Rolim Neto

Background: The induction of the formation of organoids derived from induced pluripotent stem cells (iPSC) is a new technology that is being well studied and aims to improve the clinical condition of patients with various diseases and even patients undergoing certain types of procedures.

Methods: A systematic review, using the PRISMA protocol. The study period was from 2010 to 2020 and the keywords included “Organoids”, “iPSC”, “Ethic” and “Evidence-Based Medicine”, one at a time and then combined with the Boolean operator “AND”.

Results: A total of 44 registrations were found. Of this total, 15 articles were excluded because they have not approached organoids and stem cells objectively, often attending to other phenomena or details that are not of interest to the review.

Limitations: Discoveries about organoids and new methods to promote their generation and growth are constantly being tested and developed around the world, this implies a constant renewal of sources of information. The article was based on current and highly respected sources in the scientific community.

Conclusion: Organoids are unquestionably a technology capable of changing many concepts and guidelines in the medical environment. Faced with this enormous capacity, it is necessary that studies are constantly made and that the use of this new technology is widely discussed, since it addresses not only the scientific sphere, but also the ethical sphere, the social sphere. Improving this already existing technology so that it will increasingly mimic the human body is the challenge that exists and needs to be addressed by many professionals in different areas in harmony.