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Review Article - (2022) Volume 0, Issue 0

Iatrogenic Alogenosis Due to the Use of Biopolymers

Esteban Wilfredo Vivas Erazo, Conrado de Jesús Orozco Alvaran, Frank David Almenares Gomez, Harry Estiven Acosta Bejarano, Rodolfo Jose Marquez Ustariz, Sebastian Durango Conde and William Andres Jaramillo Cabrera
1General Physician, Universidad Libre, Cali, Colombia, Colombia
General Surgery Resident, Pontificia Universidade Católica do Rio de Janeiro, Brasil
General Physician, Universidad de Antioquia, Medellín, Colombia
General Physician, Universidad del Magdalena, Santa Marta, Colombia
General Physician, Universidad Militar Nueva Granada, Bogota, Colombia
General Physician, Universidad Libre, Barranquilla, Colombia
2General Physician, Universidad de Sucre, Sincelejo, Colombia
3General Physician, Universidad Libre, Cali, Colombia

Received: 11-Mar-2022, Manuscript No. Iphsj-22-12658; Editor assigned: 13-Mar-2022, Pre QC No. PreQC No. Iphsj-22-12657; Reviewed: 27-Mar-2022, QC No. QC No. Iphsj-22-12657; Revised: 01-Apr-2022, Manuscript No. Iphsj-22-12658(R); Published: 09-Apr-2022, DOI: 10.36648/1791-809X.16.S6.924


At present, with the rise of new technologies aimed at the aesthetics of patients, it has led to the creation and administration of various filler substances in different anatomical places, in this work emphasis will be placed on injectable substances, also known by the name of biopolymers, which are macromolecules of different origins, derived from oil, plant origin and synthetic origin. The adverse effects after its administration are sometimes catastrophic and there is still not enough experience to carry out the adequate and definitive treatment, not to mention that, in the worst cases, they have fatal outcomes such as death, emphasis will be placed on mainly in complications of its use, such as iatrogenic allogeneic and its effects on health.


Iatrogenic allogenesis, Biopolymers, Complication


Iatrogenic allogenesis, Biopolymers, Complication


Biopolymers are currently widely used bio implants in the area of aesthetic and plastic surgery. The importance of this literature review lies in the fact that these substances are considered a public health problem, due to their inadequate use in the field of modern medicine., is causing irreversible injuries to patients, putting their physical integrity at risk [1].

It is known that one of the main drawbacks occurs when these substances are administered by people without expertise in the field of medicine, in establishments without any type of sanitary control, in the so-called "garage operating rooms" as a consequence this increases its many side effects. Added to this is the growing number of these products that do not meet the standards Minimum sanitary conditions to be used without risks in the human body [2].

Thus, the application of biopolymers and their adverse effects are considered a pathology called Iatrogenic Allogeneic, named in 2008 by Dr. Felipe Coffman, considered one of the pioneers in describing this pathology for the first time in Latin America, a plastic surgeon of Ukrainian nationality, but that all his life was eradicated in Colombia, thus being one of the main countries in the treatment and management of this pathology [3]. That at that time it was considered a disease with a prevalence that affects more than a million victims a year, that is, more than AIDS or tuberculosis, it deserves to be baptized and controlled. I am referring to the disasters produced by certain injectable fillers [4].

It was decided to name it this way because the disease comes from the terms "allogeneic" because it is produced by allergenic substances, that is, foreign to the body and "iatrogenic" because it is produced by the application of health personnel. In the last decade, it was considered that 358 cases of iatrogenic allogenosis occur per 1000 patients using bio implants, of which 97% are women [5].


The study design is adapted to a systematic review of the evidence present in the scientific literature on iatrogenic allogenesis due to the use of biopolymers,

The literature search took place between 2000-2021, delving into various bibliographic databases in order to obtain information and review previous studies on the exposed topic. The keywords and Boolean operators used were "allogenesis", "iatrogenic", "biopolymers", "complications", described through DeCS (Descriptors in Health Sciences). In order to obtain a greater update on the subject, the articles published in the last 20 years were set as a temporary filter for the search



Historically, bio implants have been used in Japan for many years. In the early 1940s, liquid silicone began to be used since a percentage of it could be absorbed into the body. Six years later, this substance was mixed with 1% fatty acids of animal and vegetable origin, in order to produce an irritation reaction in the surrounding tissues when injected, and later this irritation would produce a fibrous encapsulation that allowed to be fixed on the applied site. Years later, in 1949, a variety of silicone came into use in the form of a double bond gel. Thousands of breasts were injected with this gel, which was called "Akiyama's natural fat", after the Japanese surgeon who discovered it, or "surgery without a scalpel" [6].

As time passed 20 years after the Japanese advances in the field of plastic surgery, in the USA, Cronin and Gerow, from Baylor University, implanted silicone bags in a patient's breasts for the first time. These bags fulfilled the function that the material did not move. From 1940 to the present day, the use of bio implants has been widely used; more than 20 million people in the world wear silicone in various regions of the body [7].

Biopolymers most used in practice

Within the main biopolymers we will find the following: we find collagen, which can be extracted from the same patient, harvested, or it can also be of bovine origin. Continuing, we have synthetic hydroxyapatite, which is a biocompatible alloplastic material whose composition has found many similarities to hydroxyapatite found in human bone and is used as its replacement [8].

Polytetrafluoroethylene is also used, it is a polymer similar to polyethylene, it is used very frequently and it is biocompatible. Thus, hyaluronic acid is preferred by most plastic surgeons due to its characteristics and biosafety. This type of biopolymer is located in animals, in the connective tissue of mammals and the extracellular space, of non-animal origin to fill sites anatomical [9] Methacrylate, also known as polyvinyl methacrylate polymethylsiloxane, in suspension with dimethylpolysiloxane, is what is commercially known as liquid silicone. Many of these substances are inert, and will be prepared in different volumes or degrees of hardness; that is, from solid to liquid. The only biopolymers currently used in the field of medicine are biodegradable ones [10].

Complications associated with the use of biopolymers

Biopolymers are dangerous mainly due to 3 factors that are well described in the literature: The first is that they produce an excessive inflammatory reaction in the body, granulomas, because the immune system identifies the biopolymer as a foreign object and a protective reaction is triggered by encapsulating it. Secondly, they can migrate from the place where they were applied, thus causing complications in other remote sites. Finally, the third is that most of the time they do not meet the minimum health control requirements, which increases the risk of complications and secondary effects due to infection. Other important consequences of biopolymers are the local reactions that occur such as; fibrosis, lesions and changes in skin texture. In some cases it can cause death from an embolism when these substances are applied directly into a blood vessel [11],12] (figure 1,2&3).


Figure 1 Iatrogenic allogenosis in the gluteal region after injection of a substance to increase volume. Taken from: Tamayo Carbon AM, Orozco Jaramillo MA, Posada Ruiz DA. Adjuvant substances and adjuvantinduced inflammatory autoimmune syndrome. Presentation of a case. Rev Panorama. Cuba and Health.


Figure 2 Multiple erythematous plaques and nodules, well defined, indurated and adhered to deep planes, which were located in the frontal, Periorbital, intercalary, temporal, malar and nasolabial folds. Taken from: Corrales MF, Restrepo R, Calle E, Morales D. Granulomatous reaction to a sarcoid-type foreign body, secondary to biopolymers: case report and review of the literature.


Figure 3 Macroscopic appearance of the skin and deep tissue after injection of allergenic substance. A: Damaged skin, stiff. B: Oil when deep tissue is incised. C: Caverns and pearls. D: Breakage of the pearl showing the contents spilled on the glove. Taken from: Tamayo Carbón, Alicia María, Bencosme Escarramán, Yiraldi Yanet, & Medina Robainas, Rolando Ernesto. (2021). Surgical Findings In Patients With Iatrogenic ALOGENOSIS. Scientific Journal of Medical Science.

Within the complications we will most frequently find protuberances, depressions and irregularities, pain, ecchymosis or hematoma, and overcorrection. The application of hyaluronic acid has an incidence of allergic reactions of approximately 1 in 3000, while collagen of animal origin has been associated with severe local or regional allergic reactions that can become chronic and have a very poor prognosis and treatment with an incidence of 1% to 3%. It should be noted that allergic reactions are to blame for long-term scarring [13] it is also described that with lactic acid and calcium hydroxyapatite, inflammatory papules may form, mainly associated with superficial injection, and accompanied by skin discoloration. Sterile abscesses and telangiectasia’s are other reactions that can appear in early stages [14].

The tissue reaction against biopolymer infiltration can occur acutely or even late, with cases of complications appearing even up to 25 years after their application being described. (Figures 1- 3).


In different South American countries, many doctors use these applicable substances under the false argument that when used correctly, there are no side effects. It is logical that in some cases there will be no immediate alterations [16] however, this does not ensure that over the years there will be none, which is why the use of biopolymers should always be contraindicated, although these statements they are debated by many authors who support the use of biopolymers, but with all asepsis measures [17].

Thus, the great number of substances used as body fillers will be very difficult to predict their behavior. The results of histopathopathology studies are very similar; all are expressed in terms of: "fibrosis and chronic inflammation of the foreign body type", "Granulomas", "Numerous clear vacuoles, of different sizes surrounded by a lymphohistiocytic infiltrate", "Foamy appearance histiocytes containing material that refringes with light polarized and causes a vacuolized appearance", "Dystrophic calcification", "It is not possible to identify the injected substance", etc. according to Dr Coiffman's studies.

However, studies about its consequences and complications, in general, of the use of biopolymers is limited, for which the subject is still considered with many gaps and given the rise of many aesthetic therapies at the international level, it is important to cover the path what remains to be done. its figures are not clear, and in addition to the fact that studies with larger statistical groups are also needed, which accurately demonstrate its complications, there is also no standard medical conduct. Because of the growing and very lucrative black market for these products without any regulation by the health authorities of many countries [18,19].

To conclude, it is known that the ideal filler substance does not exist. Even the very tissues of the person, when they are moved, tend to undergo modifications. Autogenously fat is very well reabsorbed by more than 50% in most cases, unless it is injected into muscle tissue or into columns less than 3mm in diameter. Fascia, cartilage, bone, etc., also autogenous, do not guarantee 100% long-term survival. We can only hope that the technological advance of genetic engineering will help by producing cultured or cloned autogenous tissues to be used later [20].


The problem of biopolymers has been going on for several decades, which due to its countless and varied complications constitutes a serious health problem.

world public, the lack of effective treatment has led to many problems for the physical and emotional health of patients who undergo this type of practice, in terms of figures, in the reviewed literature there are no studies that specify this data, the increase in the rate of cosmetic surgeries where these substances are used also makes it difficult to have an exact data, finally, there are a large number of plastic surgeons who use it properly and therefore support its use, however its use always It will be a topic of debate for the different groups, at least until there are more studies about these substances, or a legislative issue where their use is regulated. "Iatrogenic Allogenosis does not physically kill the patient, but it does destroy his psyche, his self-esteem and his quality of life.


  1. Ruiz Ortega MG, Adum Ruiz J H, Alcívar Alcívar F S, Leone Jiménez P A (2021) Los biopolymers y sus consecuencias alogenosis iatrogénica. Reciamuc 5:180-188.
  2. Google Scholar, Crossref

  3. Allais M, Abreu A, Maurette P E (2015) Reacción  a  un  cuerpo  extraño  por  un  biopolímero  inyectado:presentación  de  un  caso  clínico.  Cirugía Oral y Maxilofacial 27:23-36.
  4. Indexed at, Google Scholar , Crossref

  5. Coiffman R (2008) Alogenosis iatrogénica Una nueva enfermedad Cir Plast Iberolatinoam 34:1-10.
  6. Indexed at, Google Scholar, Crossref

  7. Isaac Chavero (2010) Biopolímeros (secuelas) La revista de Cirugía Estética Disponible.
  8. Google Scholar

  9. Klein AW (2001) Collagen Substitutes Bovine Collagen Clin Plast Surg 28:35.
  10. Indexed at, Google Scholar

  11. López C (2011) Xantanos biopoliméricos Propiedades reológicas y aplicaciones. CienciAcierta 7.
  12. Google Scholar

  13. Breiner M (2007) Inyección de Colágeno En Cirugía Plástica Reconstructiva y MaxiloFacial Ed: Georgiade G. 3a. Ed W: B Saunders Co. Philadelphia 617-634.
  14. Google Scholar

  15. Mejía L (2011) Diagnóstico de la cadena productiva petroquímica plásticos y fi bras sintéticas Bucaramanga, Colombia UIS 80.
  16. Google Scholar

  17. Ripalda  A,  Loja  A,  Víctor  L,  Herrera  P, Freites  P  J et al. (2018) Consecuencias  clínicas  del  uso  de biopolímeros como prácticas de autoatención en  el  proceso  de  trasformación  corporal  en  personas transexuales. Facsalud-UNEMI 2:46-52.
  18. Google Scholar

  19. Sanz H, Eróstegui C (2010) Alogenosis Iatrogénica, el Gran Peligro de los Biopolímeros. Revista Científica de Ciencias Medicas 13:31-34.
  20. Indexed at, Google Scholar

  21. Coleman S R (2002) "Evasión de Oclusión Arterial Producida Por Sustancias de Relleno de Tejidos Suaves" Aesth Surg J 22:555.
  22. Google Scholar

  23. Duarte A, Hedo A, Pradel J, Gómez V (2016) Complicación  tardía  tras  infiltración  de  biopolímeros  en  glúteos.  Cirugía Plástica Ibero  Latinoamericana 42:385-389.
  24. Indexed at, Google Scholar , Crossref

  25. Coiffman F (2004) Los desastres de algunas sustancias inyectables de relleno. Alogenosis Iatrogénica". XV Congreso FILACP. Sevilla. España, Mayo.
  26. Google Scholar

  27. Duarte Y, Sanchéz A, Abdul Hamid, Hedo-Toledo Pradel-Radel J (2016) Complicación tardía   tras   infiltración   de   biopolímeros   en   glúteos.  Cirugía Plástica Iberolatinoamericana 42:385-389.
  28. Indexed at, Google Scholar

  29. García V (2012) Malapraxis en medicina estética Acta Bioclínica, Volumen 2, Número 4, julio-diciembre ULA 2012. Caracas: Fundación de Estudios de Medicina Estética. Sociedad Científica Venezolana de Medicina Estética.
  30. Google Scholar

  31. Madrid A, Biopolímeros y (2016) su Tratamiento [Página Web en línea]. Recuperado en 10 de mayo de.
  32. Google Scholar

  33. Gómez L, Pacheco M (2015) Alogenosis  Iatrogénica:  Características  Demográficas  y  Clínicas.  Tesis  de  grado,  Universidad  Central  de  Venezuela  (UCV),  Facultad  de  Medicina.
  34. Google Scholar

  35. Coiffman F (2000) "Inyección de sustancias alógenas. Sus peligros" Revista Sociedad Colombiana de Cirugía Plástica. Bogota.  
  36. Google Scholar

  37. Coiffman F (2007) Editor en "Coiffman. Cirugía Plástica, Reconstructiva y Estética" 3ª. Edición. Amolca. Bogotá. 2 Tomo 951.   
  38. Google Scholar

  39. Tamayo Carbón AM, Orozco Jaramillo MA, Posada Ruiz DA (2019) Sustancias adyuvantes y síndrome autoinmune inflamatorio inducido por adyuvantes. Presentación de un caso. Rev Panorama. Cuba y Salud 15:59-64.
  40. Google Scholar

Citation: Citation: La Peña Restrepo LED, Wilfredo Vivas Erazo E, Orozco Alvaran CDJ, Almenares Gómez FD, Acosta Bejarano HE, et al. (2022) Iatrogenic Alogenosis Due to the Use of Biopolymers. Health SciJ. Vol. 16 No. S6: 924.