Department of Computing and Mathematics, University of Edinburgh, UK
Mini Review
Research on Anti-Cancer Therapies
Author(s): Alesia Ivashkevich*
Despite immune checkpoint blockade's unnoticed effectiveness in providing certain non-small-cell lung cancer NSCLC patients with long-lasting responses, the majority of patients do not react. There is a correlation between PD-L1 tumour expression and pre-existing cancer T-cell infiltration and better clinical results from anti-PD-1/anti-PD-L1. Patients with tumours that do not express PD-L1 can still benefit from treatment, nevertheless. To increase the response rates to PD-1/PD-L1 antibody blocking, approaches to combine immune checkpoint inhibitors with additional therapeutic modalities, such as radiation, are being researched. RT causes immunogenic alterations in cancer cells, has the ability to adaptively upregulate PD-L1 expression in tumour cells, and can boost the effectiveness of anti-PD-1/anti-PD-L1 therapy. Future clinical trial designs for NSCLC will also be influenced .. View More»
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