West Bengal University of Animal and Fishery Sciences, India
Special Issue Article
Wide variabilities detected among spike proteins of SARS Cov2 globally- RIGI predicted to be an important immune response molecule
Author(s): Aruna Pal*
SARS Cov2 is a newly emerged virus causing pandemic with fatality and co-morbidity. The greatest limitations emerged is the lack of effective treatment and vaccination due to frequent mutations and reassortment of the virus, leading to evolvement of different strains. We identified a wide variability in the whole genome sequences as well as spike protein variants (responsible for binding with ACE2 receptor) of SARS Cov2 identified globally. Structural variations of spike proteins identified from representative countries from all the continents, seven of them have revealed genetically similar, may be regarded as the dominant type. Novel non-synonymous mutations as S247R, R408I, G612D, A930V and deletion detected at amino acid position 144 were identified and attempted to explore their functional significance. RMSD values ranging from 4.45 to 2.25 for the dominant variant spike1 w.. View More»
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