International Journal of Drug Development and Research

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Arvind Raghav

School of Pharmaceutical Sciences, IFTM University, Moradabad U.P, India

  • Research Article   
    Process Variable Studies for the Preparation of Optimized Drug Delivery System Using Central Composite Design
    Author(s): Vijay Sharma*, Ashish Singh Chauhan and Arvind Raghav

    This research work aimed to study process variable studies for the tasteless drug resin complex of Propranolol hydrochloride and Kyron-T 314. The effect of different parameters such as swelling time, stirring time, pH, Temperature, drug resin ratio, as well as resin activation, was optimized by taste and percentage of drug loading. The formulation DRC (Drug Resin Complex) was characterized by Infrared Spectroscopy. Differential Scanning Colorimetry, and X-ray Diffraction Pattern. Tablets were formulated by the Direct Compression method with Hydroxypropyl methylcellulose (HPMC) as a binder. Sodium Starch Glycolate (SSG) and Kyron-T 314 as a super disintegration, In these batches, optimum hardness was achieved but disintegration time was found to be 30 Seconds, so further trials were planned by using different super disintegrants such as Sodium starch.. View More»

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