Department of Physiology, Facultat de Medicina i Odontologia, Universitat de València, 46010 Valencia, Spain
Mini Review
MicroRNA overexpression in men with lafora disease is age-related
Author(s): Concepcion Aguado*
Lafora complaint is a rare, fatal form of progressive myoclonus
epilepsy characterized by nonstop neurodegeneration with epileptic
seizures, characterized by the intracellular accumulation of aberrant
polyglucosan grains called Lafora bodies. Several workshop have
handed multitudinous substantiation of molecular and cellular
differences in neural towel from experimental mouse models deficient
in either laforin or malin, two proteins related to the complaint.
Oxidative stress, differences in proteostasis, and deregulation of
seditious signals are some of the molecular differences underpinning
this condition in both KO beast models. Lafora bodies appear
beforehand in the beast’s life, but numerous of the forenamed
molecular aberrant processes and the consequent neurological
symptoms postdate only as creatures age. Then, using small R.. View More»
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