Clinstinct Clinical Research, Bhubaneswar, Odisha 751030, India
Research Article
In Silico Molecular Docking Analysis of Potential Anti-Alzheimer's Compounds Present in Occimum Santum
Author(s): Dr. Susanta Kumar Rout*, Ms. Farhin Nikhat and Sabyasachi Mohanty
Objective: Alzheimer’s disease (AD), a progressive neurodegenerative disorder with many cognitive and neuropsychiatric symptoms, is biochemically characterized by a significant decrease in the brain neurotransmitter Acetylcholine (ACh).
Methods: : In the present insilico study, four plant bioactive compounds of Ocimum sanctum were analyzed for their inhibitory role on AChE (Acetylcholinesterase) and BChE (Butyrylcholinesterase) activity by applying the molecular docking studies. Other parameters viz. determination of molecular interaction-based binding affinity values, protein-ligand interactions, Lipinski rule of five, functional properties and biological activities for the above compounds were also calculated by employing the appropriate bioinformatics tools. The active compounds is to reveal its potentiality by molecular docking analysis to find out its potent compo.. View More»
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