Centre for Plant and Water Science, Faculty of Sciences, Engineering and Health, CQ University, Rockhampton, Queensland 4702, Australia
Expert Review
Towards the Synthesis and Genetically Screening of a Halisarca ectofibrosa
Author(s): Elisa Mark*
The first solution-phase synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) was accomplished by coupling dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. The deportation of the linear tetrapeptide unit and subsequent cyclization produced a cyclopeptide that was identical in every way to the naturally occurring compound. The bioactivity results showed that the synthesised peptide had antifungal and antihelmintic properties against pathogenic dermatophytes and earthworms.
Keywords
Natural product synthesis; Marine bacteria; cyclic tetra peptide; Biological activity .. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 