Assiut Health Directorates, Egypt
Mini Review
Update on pleiotropic immunologic and potential antiviral effects of antibiotics and their clinical impact
Author(s): Romany Helmy Thabet*, Sana'a Mahmoud Muflih Bani Amer, Hamam Hani Nageeb Dwaghreh, Ansam Zakaria Issa Baniamer, Mohammad Rami Mohammad Tbaishat and Erin Maher Wilson
While antibiotics are widely used as antimicrobial agents for treating a variety of bacterial infections, it has been reported that a majority of them also exert antiviral, anti-inflammatory, immunomodulatory, and antioxidant activities that may a significant role in alleviating many clinical disorders such as severe acute respiratory syndrome coronavirus 2 (SAR-SCoV-2). Interestingly, literature mentioned that macrolide antibiotics (e.g., azithromycin) significantly reduce viral replication, downregulate the inflammatory cascade and excessive cytokine production, and decrease mortality. In the same line, fluoroquinolones as moxifloxacin and ciprofloxacin suppress COVID-19 replication, overproduction of nitric oxide in the lungs besides inhibiting inflammatory cell responses. Similarly, various antibiotics, such as doxycycline, clarithromycin, ceftriaxone, amoxicillin, amoxicillin-cla.. View More»